Microglia Make Tau, Spelling Their Demise in Tauopathies
When carrying a pathogenic tau variant, microglia were bad at phagocytosis, barely made TREM2, and spat out neurotoxic proteins.
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Neuron-Glia Crosstalk Underlies Senescence, Impaired Lipid Metabolism
As flies age, mitochondrial damage in their neurons somehow ages glia, which, in turn, cause lipid droplets to pile up on other, healthy glia.
Caught in the Act: Cryo-EM Exposes γ-Secretase Catalytic Pose
The enzyme cleaves off three amino acids at a time with a twist of the substrate, and a helping hand from a β-strand.
Rubbing Microglia the Right Way? At ADPD, Scientists Showcase New Strategies
Preclinical studies and early phase trials target microglial receptors CD33 and TREM2, and amyloid-stoking ASC specks.
Over the Span of AD, Roles of Astrocytes and Microglia Change
Reactive astrocytes spell trouble for synapses, while microglial transform from protective to destructive as disease progresses.
Could Sumoylation Take Down Tangles?
The addition of SUMO2 to tau prevents its phosphorylation and aggregation, preserving synapses and memory in tauopathy mouse models.
p-Tau217 Immunotherapy Alleviates Tangle Pathology in Mice
Two antibodies—one against the phosphoprotein, the other to tau’s N-terminus—restored proteostasis in the brain.
CSF Hugs Arteries to Squeeze into the Brain
Cerebrospinal fluid rides the pulses of cerebral arteries to enter the brain and spread into cortical tissue. This supports the existence of a human glymphatic system.
Organization of Aβ Plaques and Tau Tangles Illuminated in AD Brain
Plaques comprise different-sized fibrils and cell membrane components, while tangles have distinct fibril structures segregated into intra- and extracellular compartments.
Does Tangle Progression Follow ApoE Expression?
Correlating PET imaging with spatial transcriptomics revealed paths for the progression of tau pathology throughout the brain.
Behold, Plaques Mapped in Whole Brain at High Resolution
Advances in microscopy yield unprecedented views of Aβ plaques in vivo and ex vivo. The vistas offer new insights about how plaques form, grow, and clear.
Receptor Decoy Raises Risk of Alzheimer’s—But Only in Women
High sST2, an IL-33 receptor fragment, raises the odds of Alzheimer’s in women who carry APOE4. A variant that lowers sST2 mobilizes microglia, protects against AD.
Sylvain Lesné, Who Found Aβ*56, Accused of Image Manipulation
Other scientists found indications of potentially doctored western blots in multiple papers, including several on Aβ*56. Investigations are underway at journals, NIH, UMinnesota.
Don’t Name It: Glial States Confound Easy Labels
By consensus, leaders in the astrocyte and microglia fields recommend that investigators eschew names in favor of detailed descriptions of reactive glia, with a focus on functional changes.
In Parkinson’s, Synuclein Fibrils Fold Differently Than in MSA
Synuclein fibrils from Parkinson’s disease, PD dementia, and dementia with Lewy bodies share the same protofilament structure. MSA fibrils are different.
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