Do Tau Fibrils Form Via Droplets?
In cultured cells, mutant human tau that was forced together formed liquid droplets. When tau was missing its N-terminus, the droplets hardened into insoluble aggregates.
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Do Rod-Shaped Microglia Dampen Hyperexcitability in ALS?
These microglia formed soon after overexpressing TDP-43 in a transgenic mouse. The cells pruned excitatory synapses, cooling circuits and extending lifespan.
C1q from Microglia Meddles in Neuronal Translation
In mice, the innate immune protein slips into neurons, where it interacts with the translation machinery.
A First for Proteinopathies—Heteromeric Fibrils
In people with FTLD-TDP-43 Type C, TDP-43 and annexin A11 twist into heteromeric amyloid filaments. Could there be others?
Donanemab Approved in the U.S.
The antibody becomes the second amyloid immunotherapy to receive traditional FDA approval, joining Leqembi.
PET Tracers For Non-Alzheimer’s Tauopathies Enter Clinical Testing
New candidate OXD-2314 binds 3R and 4R forms of tau and has begun Phase 1. The pan-tau tracer APN-1607 begins Phase 3 for progressive supranuclear palsy, a 4R tauopathy.
Remember Amyloid-eta? A Decade Later, News on a Physiological Function
To modulate synapses, Aη weakens ion flux through glutamate receptors and strengthens their non-ionotropic signaling. This dual action is a first, say scientists.
T Cells in the Brain Goad Microglia to Muddle Myelin
In mouse models of amyloidosis, CD8+ T cells trigger myelin pathology by rousing microglia and confusing oligodendrocytes.
Microglial Transplants Reverse Age-Related Pathology in Mice
Mice missing microglia develop astrogliosis and neurodegeneration by middle age. Giving them healthy microglia prevents or reverses pathology.
Toward an AD CRISPR Therapy: Tweaking APP Terminus Cuts Plaque
Nixing an endosomal targeting sequence shields APP from BACE1, reducing Aβ and pathologic C-terminal fragments in mice.
All About Exposure: How to Get Enough Progranulin into the Brain?
Injected into the cerebrospinal fluid, a viral vector delivers the lysosomal protein into the human brain. In mice, a protein transport vehicle delivered into the blood does the same.
Blood May Foretell Parkinson’s Up to Seven Years Prior
A panel of eight plasma proteins identified people who were on the path to Parkinson’s. Could this help select participants for prevention trials?
Donanemab Approval Likely to Pose New Quandaries for Clinicians
With limited guidance, physicians will have to navigate questions about whom to treat, when to stop, and how to manage safety.
New PET Ligand Captures α-Synuclein in Parkinson’s, MSA Brains
C05-05 binds α-synuclein deposits in the mouse, marmoset, and human brain. Uptake in the PD midbrain correlated with motor symptom severity.
Unanimous: FDA Advisory Committee Backs Donanemab
All 11 committee members voted that the antibody was effective for people with MCI or mild AD dementia, with its benefits outweighing risks.
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