European Regulators Turn Down Aduhelm; Price Drops
The EMA's decision was expected. Biogen announced it will appeal but also halved the drug's price. The company said it plans to complete a confirmatory trial by 2026.
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Deep Sleep Accelerates Synuclein Removal in Mice
Parkinson’s mice that got deeper slow-wave sleep cleared synuclein deposits, perhaps via better glymphatic function. Sleep deprivation worsened synuclein phosphorylation and aggregation.
Amyloids Fibrillize, or Stay Solo, Based on Liaisons with Like Proteins
For amyloidogenic proteins such as Aβ and tau, third-party proteins bearing similar sequences sway aggregation kinetics. Does this underlie cells’ selective vulnerability to amyloid?
Aduhelm Phase 3 Data: ARIA Is Common, Sometimes Serious
Among those on the high dose, 41 percent developed ARIA, 1 percent had serious symptoms, some had recurring ARIA. Impending CMS decision draws debate.
Does Viagra Make for More Vigorous Brain, Lower Dementia Risk?
A repurposing study tapped sildenafil as an Alzheimer’s drug candidate. It suppresses p-tau in cultured neurons, men who take it are less prone to AD, and a trial is planned.
Double Spiral Sets TDP-43 Apart from Other Amyloids
Cryo-EM revealed that TDP-43 protofilaments from people with ALS/FTD formed the same structure, with a core of stacked double spirals. It is wildly different from that of TDP-43 filaments made in vitro, and from those of other amyloids.
Paper Alert: Runners’ Plasma Calms Inflamed Mouse Brain
Blood from fit mice reduced neuroinflammation in inactive mice. The can-do component? Clusterin, an apolipoprotein linked to Alzheimer’s. Clusterin tamped down interferon and cytokine signaling.
Bringing Alzheimer’s Detection into the Digital Age
At CTAD, scientists presented an electronic version of the CDR, plus new digital tests. Will smartphone apps pick up mild cognitive impairment and even preclinical cognitive change?
Could Targeting CD22 Restore Microglial Lysosome Trafficking?
In human microglia-like cells, soluble CD22 stalled normal breakdown of fats. Blocking sCD22 greased the system, evoking a treatment for lysosomal-storage disorders.
The Rain in Spain: Move Over Higgins, AI Spots Speech Patterns
AI-powered apps catch changes in how a person speaks that may reveal cognitive decline in frontotemporal dementia and early Alzheimer’s. Can smartphones deliver biomarkers for trial enrollment and diagnosis?
Massive Proteomics Study Connects Genes, Proteins, Disease
By integrating plasma proteomics data from 35,000 Icelanders with data on disease-associated variations in their genomes, scientists cinched connections between gene variants that change protein levels in plasma, causing disease.
TREM2 Risk Variant Eggs on Clique of Microglia in AD Brain
Transcriptomics pinpoints an expansion of pro-inflammatory microglia in people who carried the R47H-TREM2 variant. A similar cadre of microglia arose in female tauopathy mice carrying a single copy of the AD risk variant.
Young ApoE4 Carriers Have Reversed AD Proteomic Signature
The same 24 proteins that are downregulated in an Alzheimer’s proteomic study are turned up in young APOE4 carriers. Two proteins, the kinases Yes1 and Fyn1, are targets of the drug dasatinib, which is being tested as an anti-aging senolytic in AD.
Brain Shuttle Could Halve Amount of Gantenerumab Needed
While Phase 3 trials of subcutaneous gantenerumab continue, scientists say delivering the antibody to the brain via the transferrin receptor might be twice as efficient.
Toxic Delivery: Do Microglia Unwittingly Sprinkle Aβ Around the Brain?
In a mouse model of amyloidosis, microglia carried Aβ aggregates into grafted wild-type tissue. The immune cells played a key part in the subsequent growth of plaques in the graft.
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