Human Cell Models Reveal Two Sides to α-Synuclein Inclusions
Dynamic, lipid-rich inclusions of α-synuclein appear toxic, while stable, fibril-rich aggregates seem to protect neurons.
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Put a RING on It: Targeting Intracellular Tau Aggregates for Destruction
A new strategy, which marries nanobodies or misfolded tau to a ubiquitin ligase RING domain, tags tangles for disposal.
MODEL-AD Probably Has Something for You
The consortium has cranked out dozens of mouse models of late-onset AD for the research community. Strains carry humanized Aβ and tau, and a growing list of risk variants.
Could “Big Tau” Protect Brain Regions from Tangles?
This super-sized isoform resists phosphorylation and aggregation, and occurs in cerebellum and brainstem, regions largely spared from tau pathology.
A Country Doctor, But Oh So Much More: Francisco Lopera, 73
The indefatigable Colombian neurologist leaves behind a legacy of Alzheimer’s prevention research, which, at the time of his passing, stands on the cusp of success.
Nix Tryptophan Metabolite, Temper Alzheimer’s?
Kynurenine curbs lactate production in astrocytes, which then fail to nourish neurons. Shutting down kynurenine production rescued cognition in AD mouse models.
That Retrotransposon in TMEM106b: Friend or Foe?
How—or even if—a newly spotted AluYb8 element raises risk of neurodegenerative disease has become a question of intense interest. Centenarians, it seems, are spared.
Questions, Questions for Donanemab, Lecanemab
As immunotherapies enter care, scientists explore when to stop them, how amyloid removal relates to cognitive benefit, and whether fluid markers will track both plaque and tangles responses.
Is the ‘Atrophy’ of Immunotherapy Just the Dismantling of Plaque ‘Suburbia’?
Plaques and their surrounding cells and neurites occupy 6 percent of cortical volume. Their removal could account for shrinkage during amyloid immunotherapy.
Liraglutide Trial Was Negative Four Years Ago, Still Negative Today
Contrary to media stories, results of a small trial, which finished four years ago, did not demonstrate protection against cognitive decline or against brain shrinkage in people with Alzheimer’s.
Tau Tangles Linked to ‘Lonely’ Brain Waves, Forgetfulness
During non-REM sleep, waves of activity that wash slowly across the cortex help consolidate memories. Tau pathology in the frontal cortex breaks them up.
Transcriptomics Paint Astrocytes as Source of Cognitive Resilience
In people who fended off cognitive slippage despite a hefty load of plaques and tangles, astrocytes cranked up choline and polyamine synthesis.
Tau PET Misses Early AD Pathology, Primary Age-Related Tauopathy
The largest autopsy-confirmed study of tau PET to date finds that the scans cannot identify early Alzheimer’s disease or PART.
Perineuronal Pockets Prevent Spillage from Synapses
Synapses of fast-spiking interneurons nestle in holes within dense extracellular matrix. These ‘cages’ corral glutamate, so it won’t spark excitotoxicity.
Part with PILRA, Power Up Microglia?
Knocking out this immunoglobulin receptor makes microglia fit to fight. An anti-PILRA antibody does the same.
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